Ligatures in minuscule text confuse me. I do not understand their squiggles and coalescing of letters. Their strange forms frighten me with their letter-like shapes and unfamiliar conglomerations.
Now, I may just be a simple caveman, unfrozen from my chilled stupor by your "modern science"; I may be simple in my approach to things text-critical.
But one thing I do know: If a critic is confused by abbreviations in Greek inscriptions/papyri/etc., said critic should consider purchase of Abbreviations in Greek Inscriptions: Papyri, Manuscripts, and Early Printed Books by Al. N. Oikonomides for enlightenment (at least according to the bottom of this page from Gary Dykes). I have done this; I will report back on its utility once I am in receipt of said tome.
[for those who don't get the joke — google "Unfrozen Caveman Lawyer" for enlightenment]